Tinnitus and Phantom Pain—The Links are Clear

Last Updated November 1, 2022

Arash G

By Arash G

GM House of Hearing Clinics

tinnitus and phantom pain

Some fifteen percent of Americans suffer from tinnitus—those persistent and irritating noises in the ears. The number of in-depth studies dedicated to uncovering the mysterious origins of tinnitus has escalated during the last ten years in response to this increasingly common and potentially debilitating condition. Interestingly, past research has drawn attention to the similarities between tinnitus and the phantom pain that many amputees experience after the loss of a limb. However, the mechanisms responsible for the ongoing pain, or noise in the case of tinnitus sufferers, have not been fully understood.

Fortunately, the latest ground-breaking research from neuro-scientists at the Georgetown University Medical Centre and Germany’s Technische Universität München has filled in many of the missing pieces of the jigsaw.

It seems that at last, researchers may be honing in on potential avenues for a cure for tinnitus.

The brain is at the heart of tinnitus and phantom pain

Both tinnitus and phantom limb pain are the brain’s response to damage or trauma. In both cases, the pain and the noise are perceived by the brain but clearly cannot exist in the physically absent limb or be perceived by the damaged ear.  The neurons in the damaged ear or connecting to the absent limb are trained to “fire”—that is their job. However, in some people, the neurons continue to “fire” off false or ghost messages.

Josef Rauschecker, director of the Georgetown research team, notes that “Some people call these phantom sensations, but they are real, produced by a brain that continues to ‘feel’ the initial injury because it cannot down-regulate the sensations enough. Both conditions are extraordinarily common, yet no treatment gets to the root of these disorders.”[1]

Some successful symptom relief has been achieved using mirror boxes to treat phantom pain. Mirror boxes allow the patient’s brain to process or feel the remaining limb as if it were the missing limb. This mental trick is also at the heart of therapies where similar sound frequencies are used to mask tinnitus or reprogram the brain to perceive sound in a different way. But this latest research could open the door to finding a real cure for tinnitus and phantom pain.

Brain plasticity—the cause and the solution

Researchers have traced the pathway of these troublesome noise and pain signals through the brain and have identified the neural gateways that inhibit these signals in a normal brain. Rauschecker noted that “These areas act as a central gatekeeping system for perceptual sensations, which evaluate the affective meaning of sensory stimuli — whether produced externally or internally — and modulates information flow in the brain. Tinnitus and chronic pain occur when this system is compromised.”[2] These neural pathways are almost identical in tinnitus and “phantom pain” suffers.

In other words, in attempting to process the signals from the damaged areas the brain’s extraordinary ability to adapt has somehow malfunctioned. The system involved in this process is also responsible for moderating the intensity of the perceived noise or pain. The exciting aspect of these findings lies in the brain plasticity that created the false pathways. It appears that the neurotransmitters, dopamine, and serotonin, play a key role in modifying the behavior of these gateways. Therefore, it is conceivable that drugs with the ability to modulate dopamine levels may help to restore normal gateway function and allow the brain to inhibit phantom noise and pain. It is perhaps no coincidence that the affected areas are where the brain processes emotion, reward, learning, and decision-making.

What does this mean for you?

The fact that these same areas of the brain are responsible for emotional response and the evaluation of noise events goes a long way to explaining some of the problems associated with tinnitus, such as insomnia, hypersensitivity to noise, and depression. However, more research is needed to explore these correlations further.

We also know that long-term stress is an important factor in predisposing someone to tinnitus and “phantom pain” but we don’t fully know why some people are more likely to develop tinnitus than others. Further research is needed to identify the genetic factors involved and to develop tools to strengthen resilience in susceptible brains. We also need to know more about the way dopamine works to bring about these brain modifications.

However, the possibility that these brain changes are reversible gives real hope for a cure.

Come and visit us at https://www.houseofhearing.ca/ to keep up to date with all the latest research.

[1] http://www.eurekalert.org/pub_releases/2015-09/gumc-nub091615.php

[2] http://www.eurekalert.org/pub_releases/2015-09/gumc-nub091615.php

More From our Library

Presbycusis age related hearing loss

What is Presbycusis, and What Causes It?

Age related hearing loss due to natural aging is called presbycusis. It’s one of the most common forms of hearing loss and affects millions of adults over 50. Age related…
Symptoms of Hearing Loss

Common Symptoms of Hearing Loss

Do you have trouble hearing? Hearing loss is a common problem that affects millions of people. The World Health Organization estimates that by 2050 one in four individuals will experience…
Best Hearing Aids Canada

The Best Hearing Aids Canada 2023

Hearing aids are a common way to help those with hearing loss regain their hearing while still enjoying the sounds of life. With so many options on the market, choosing…
Phonak Lumity Hearing Aids info

Phonak Lumity Hearing Aids

If you’re looking for hearing aids that will help you understand conversations better and make listening easier, then you’ll want to check out Phonak Lumity hearing aids. With Phonak SmartSpeech…

More From our Library
How do tinnitus maskers work

How do tinnitus maskers work?

Annoying noises (tinnitus) in your ears are one of the first symptoms of hearing loss. Tinnitus affects large numbers of…